Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects
Furthermore, this study also found that the level of ZDHHC7 autopalmitoylation, which mediates GSDMD palmitoylation, was elevated, suggesting that LPS may induce GSDMD palmitoylation through this mechanism (78)
10.1056/NEJMra2026131 N Engl J Med
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In fact, the 75-year-old actress told Park Magazine, "Aging is amazing
Deutz et al